Muscle histology
Anatomy · Topic 67
Source: NMC CBME Curriculum 2024 · Volume I · Anatomy · Topic 67 · combined PDF page 144
Practice questions
- In a patient with a suspected genetic neuromuscular disorder and a newly identified candidate gene, what is a key role of muscle biopsy?
- A biopsy is obtained from a patient with suspected acquired inflammatory myopathy. Which use of histology is supported by the supplied review?
- Which preparation approach is specifically emphasized for reducing artifact during muscle biopsy evaluation?
- Which combination best describes the routine and additional approaches to muscle biopsy assessment highlighted in the review?
- A trainee compares a child's muscle biopsy with an adult reference and assumes that normal muscle histology is identical at all ages. Which principle should correct this assumption?
- Which structural organization is identified as relevant background knowledge for interpreting neuromuscular muscle biopsies?
- A biopsy includes tissue near a muscle-tendon interface, and the interpreting pathologist is cautious about overcalling an unusual appearance. Which issue is specifically recognized as a potential interpretive pitfall?
- A pathologist is asked to compare specimens from two different muscle sampling sites. Which interpretive principle is most appropriate?
- Which pair of tissue processes is highlighted as important to understand when evaluating muscle biopsy morphology?
- A biopsy shows an abnormal pattern, but the clinical team is considering several acquired and genetic myopathies. Which diagnostic contribution of muscle histology is emphasized in the review?
- A patient has muscle weakness and reduced muscle mass following a peripheral nerve disorder. Which definition best fits neurogenic atrophy?
- In a patient with muscle dysfunction, which statement best describes the diagnostic value of histologic findings suggestive of denervation?
- Which set of molecular processes is described as part of the shared mechanisms of neurogenic muscle atrophy and other forms of muscle atrophy?
- Muscle biopsy from an infant with severe prenatal-onset weakness and arthrogryposis shows intense oxidative rims beneath the sarcolemma and scattered sarcomere remnants with enlarged Z-bands. Which association is most consistent with the reported cases?
- In the reported ASCC1-related families, which biopsy observation was proposed as a potential histopathological hallmark?
- A biopsy from an infant with prenatal-onset muscle weakness, neonatal hypotonia, arthrogryposis, and congenital fractures shows the reported oxidative subsarcolemmal rims. Which additional histologic feature was described in the same disorder?
- In a randomized study of patients with peripheral arterial disease, what happened to type I and type II fiber area after treadmill training?
- In the same peripheral arterial disease trial, which histologic change was associated with treadmill training?
- A patient with peripheral arterial disease improves peak exercise performance after treadmill training. Which conclusion about muscle citrate synthase activity matches the reported study?
- In the peripheral arterial disease trial, which intervention improved peak exercise performance and peak oxygen consumption?
- In the cited peripheral arterial disease study, what was reported for citrate synthase activity in the strength-training group?
- A study participant's exercise performance improves after treadmill training despite no increase in citrate synthase activity. Which interpretation is most consistent with the study's conclusion?
- After 18 weeks of simvastatin or pravastatin monotherapy in hypercholesterolaemic patients, what did quadriceps biopsy assessment show?
- In the statin monotherapy study, which exercise-related muscle markers were assessed, and what was the reported treatment effect?
- A patient taking simvastatin has no change in biopsy histology in a study but shows a greater LDL-cholesterol reduction than the pravastatin group. Which statement accurately reflects the study?
- A biopsy report is being used to decide whether a genetic variant is disease-causing. Which approach is most consistent with the literature on muscle biopsy evaluation?
- A clinician asks whether a muscle biopsy can be used to assess the success of immunosuppressive treatment in an acquired inflammatory myopathy. Which answer is best supported?
- A patient with suspected muscle disease has an inconclusive biopsy appearance. Which general principle is most appropriate before assigning a precise diagnosis?
- A pathology service is establishing a basic muscle biopsy workflow. Which option best matches the key elements highlighted for routine evaluation?
- Which statement best characterizes the scope of muscle biopsy interpretation described in the review?
- In the peripheral arterial disease training study, improvement in exercise performance was associated with what metabolic observation?