Obstructive Airway Diseases
General Medicine · Topic 28
Source: NMC CBME Curriculum 2024 · Volume II · General Medicine · Topic 28 · combined PDF page 323
Practice questions
- A systematic review and meta-analysis evaluated interventions targeting treatable traits in obstructive airway diseases. Which set of trait domains was represented in the included approach?
- In a meta-analysis of controlled trials of treatable-trait interventions for obstructive airway diseases, which result was reported for hospitalizations?
- Which outcome in the treatable-traits meta-analysis was reported as a mean difference of −6.96 (95% CI −9.92 to −4.01)?
- Which statement best characterizes the evidence base for treatable-trait interventions in obstructive airway diseases in the cited systematic review?
- A clinician is considering home nebulized maintenance therapy for a patient who finds handheld inhalers difficult to use. Which conclusion is best supported by the cited consensus document?
- Which combination of factors was proposed as contributing to increased home nebulizer use for maintenance treatment of obstructive airway diseases?
- The home-nebulization consensus document noted that the last international guidelines available to its panel had been published in 2001. What concern did the panel emphasize?
- A patient with COPD and excessive airway secretions is being considered for intrapulmonary percussive ventilation (IPV). Which conclusion best reflects the systematic review?
- What did the systematic review report regarding intrapulmonary percussive ventilation in the included cystic fibrosis studies?
- Which appraisal best describes the size and limitations of the IPV evidence reviewed in chronic obstructive airway diseases?
- Why may pertussis vaccination be relevant to adults with asthma or COPD, according to the cited meta-analysis?
- In adults receiving active standard treatment for obstructive airway disease, what did the meta-analysis find about reduced-antigen Tdap vaccination?
- One month after reduced-antigen Tdap vaccination in the adults with obstructive airway disease included in the meta-analysis, which proportions achieved seroprotective anti-diphtheria and anti-tetanus antibody concentrations, respectively?
- A nationwide Dutch cross-sectional study assessed medication dispensing for asthma or COPD in relation to livestock farms. Which association did it report?
- In the same study, how did the association for modeled non-farm particulate matter compare with the association for livestock-related particulate matter?
- A patient labeled as having severe COPD has persistent blood eosinophilia, a history of asthma, and nasal polyposis. Which interpretation is most consistent with the cited review?
- Which statement best reflects the inflammatory patterns described in the review of blood eosinophilia in chronic obstructive airway diseases?
- According to the review, how should blood eosinophilia be used when considering personalized therapy in chronic obstructive airway diseases?
- In the case described in the eosinophilia review, what was reported after mepolizumab was added to triple inhaled therapy following reassessment to severe eosinophilic asthma?
- Which description best defines cellular senescence in the review of obstructive airway diseases?
- A senescent airway cell remains metabolically active and releases cytokines, chemokines, growth factors, matrix metalloproteinases, and oxidative mediators. What is this secretory pattern called?
- Which combination of pathways or cellular stresses is described as contributing to senescence in obstructive airway diseases?
- A researcher proposes that disease management should focus on identifying high disease activity before disease-related damage is established. Which appraisal best represents the cited review's position?
- What is the central contrast proposed by the disease-activity review for obstructive airway disease management?
- A patient with obstructive airway disease has a biomarker associated with adverse outcomes. Based on the cited disease-activity review, what is the most defensible implication?