Conjunctiva
Ophthalmology · Topic 3
Source: NMC CBME Curriculum 2024 · Volume III · Ophthalmology · Topic 3 · combined PDF page 415
Practice questions
- Which statement best describes the timing of the first reported establishment of conjunctival organoids derived from adult stem cells, according to the supplied review?
- Which conjunctival cell type is specifically included in one of the full-thickness organoid models described in the review?
- A laboratory wants to use conjunctival organoids to study viral infection and screen candidate drugs. Which interpretation best matches the review?
- A patient asks whether conjunctival organoid transplantation has been proven safe in people. Which response is most consistent with the supplied review?
- A conjunctival mass shows regular stratified squamous epithelium with goblet cells, epithelial invaginations into stroma, and multiple pseudoglandular structures. There is no nuclear atypia or mitotic activity. Which diagnosis best fits these findings?
- Why is recognition of conjunctival pseudoglandular hyperplasia clinically important?
- In the reported case of conjunctival pseudoglandular hyperplasia, what was the lesion location and management described?
- An older adult has asymptomatic bilateral conjunctival masses. Biopsy shows mature CD4+ lymphocytes with T-cell receptor gamma gene rearrangement, and evaluation finds no disease elsewhere. Which conclusion is best supported by the supplied report?
- A conjunctival biopsy shows a clonal T-cell population. Which inference is most appropriate based on the supplied literature?
- A conjunctival lymphoid proliferation has features overlapping reactive hyperplasia and lymphoma and cannot be readily classified. What approach is supported by the case review?
- An older adult has a white leukoplakic lesion of the superior palpebral conjunctiva. Which diagnosis should be considered even though it is rare in adults?
- After excisional biopsy establishes conjunctival Langerhans cell histiocytosis, which additional evaluation was reported to assess for disease beyond the ocular lesion?
- For an older patient with palpebral conjunctival Langerhans cell histiocytosis, which management and follow-up approach is advocated in the supplied report when closure morbidity is minimal?
- A persistent pink, nontender bulbar conjunctival lesion in an adolescent is excised. Histology shows benign smooth muscle bundles in the substantia propria, positive for smooth muscle actin, vimentin, and desmin. What is the most likely diagnosis?
- Which lesion should be considered in the differential diagnosis of a persistent pink conjunctival lesion in an adolescent that does not improve with medical management?
- A patient has a blue-black pigmented lesion of the palpebral conjunctiva. Which benign melanocytic lesion should be included in the differential because it can mimic melanoma?
- Which pairing of blue-nevus variant and palpebral conjunctival location was reported in the supplied case series?
- Two patients with palpebral conjunctival blue nevi underwent excision. Which statement accurately reflects the reported follow-up?
- According to the conjunctival reconstruction review, which situation can create a need for conjunctival reconstruction?
- After substantial conjunctival injury, fibrosis and contracture develop. Which ocular-surface consequences are specifically noted in the reconstruction review?
- A patient has a large conjunctival defect after repeated surgery. Why might an alternative graft or tissue-engineering approach be needed?
- A clinician is considering management of a superficial conjunctival foreign body in an office setting. Which statement is most consistent with the supplied review?
- A clinician assessing a superficial conjunctival foreign body is unsure whether office management is appropriate. Which principle is supported by the supplied review?
- A conjunctival lesion has gland-like spaces but is lined by regular squamous epithelium containing goblet cells and shows no atypia or mitoses. Which feature most strongly favors benign pseudoglandular hyperplasia over the malignant mimic emphasized in the report?
- Which statement best distinguishes the evidence level of conjunctival organoid transplantation from a recommendation for routine human care?
- A patient with extensive conjunctival scarring after chemical injury is being considered for reconstruction. Which statement best reflects the rationale for reconstruction described in the review?
- A conjunctival mass in an older adult has a biopsy showing a clonal lymphoid population, but the findings overlap with reactive hyperplasia and no disease is identified elsewhere. Which approach best avoids overinterpreting the biopsy?