Retina&opticNerve
Ophthalmology · Topic 9
Source: NMC CBME Curriculum 2024 · Volume III · Ophthalmology · Topic 9 · combined PDF page 417
Practice questions
- In the cited zebrafish retinal-injury study, which cell population was newly reported as an additional source of regenerating retinal neurons?
- Before injury, which marker set was associated with the additional mesenchymal-derived progenitors in the zebrafish regeneration study?
- After genetic ablation of zebrafish retinal ganglion cells, which change in the reported progenitor population was observed?
- Which approach in the zebrafish study supported the conclusion that the marked progenitors contributed to later retinal neurons?
- What did the zebrafish lineage-tracing report indicate about the generation of post-mitotic ganglion-cell-layer neurons from the additional progenitor population?
- Which statement best describes insulin in the cited zebrafish regeneration preprint?
- Which conclusion about the zebrafish regeneration findings is most defensible when applying them to human ophthalmology?
- In the broad projection pattern described for mammals with frontal eyes, fibers from which retinal region predominantly project to the contralateral hemisphere?
- Which projection is predominant for fibers arising from temporal retina in the pattern described by the primate projection study?
- A student describes the nasal-temporal division of retinal projections as an absolutely sharp boundary. Which correction is consistent with the cited study?
- What functional advantage did the cited study propose for overlapping crossed and uncrossed retinal projections near the vertical meridian?
- How did the cited study assess whether the observed projection pattern could support disparity processing in natural viewing?
- Which statement about human vision near the vertical meridian matches the findings reported in the primate projection study?
- In an adult rat optic-nerve-crush time-course experiment, at which sampled times did the cited study report increased proNGF and reduced TrkA?
- Which pattern was reported for GFAP and p75NTR after rat optic-nerve crush?
- Which course of apoptotic-pathway activation did the rat optic-nerve-crush study report?
- A researcher observes increased endogenous NGF after optic-nerve crush and concludes that RGC degeneration must have been prevented. Which observation from the cited rat study most directly challenges that inference?
- What interpretation did the authors propose for the later increase in proNGF and p75NTR-related signaling after optic-nerve crush?
- Which set of post-crush sampling times was used in the rat study of retinal NGF signaling?
- In the fish retina study, what was the reported effect of short-term dark adaptation on connexon density in outer horizontal-cell gap junctions?
- In the same fish study, short-term light adaptation was associated with which connexon-density pattern?
- Under a 12-hour red-light/12-hour dark cycle in the fish retina experiment, where was a significant light-dark difference in connexon density reported?
- Under a white-light/dark cycle in the fish study, which compartment showed a significant light-dark difference in connexon density?
- What was the reported effect of optic-nerve crush on connexon density in fish horizontal-cell gap junctions?
- In white-light-adapted fish, which statement best captures the reported dopamine result?