Skeletal Trauma, Poly trauma
Orthopedics · Topic 1
Source: NMC CBME Curriculum 2024 · Volume III · Orthopedics · Topic 1 · combined PDF page 444
Practice questions
- In the mouse burn-trauma experiment described by Tomera and Lilford, which muscle was assessed for twitch tension?
- Which burn-severity groups were included in the mouse experiment relating inositol derivatives to skeletal muscle tension?
- At what time point after the mouse burn injury were muscle tension studies performed in the reported experiment?
- In which groups did the burn study find a relationship between physiological tension and the three measured poly-inositol variables?
- Which method was used to assess skeletal muscle tension in the mouse burn experiment?
- A researcher finds an association between muscle tension and measured inositol derivatives in burned mice. Which interpretation best matches the supplied study?
- In the study of severely traumatized patients, which relationship between muscle protein breakdown and synthesis characterized the reported hypercatabolic state?
- Compared with healthy controls, which change in muscle EEF1A1 messenger RNA was reported in severely traumatized patients?
- What change in EEF1A2 mRNA was reported in skeletal muscle from severely traumatized patients compared with controls?
- Which statement best describes the p66(ShcA) and c-MYC findings in muscle from the severely traumatized patients?
- Which muscle gene-expression measures were reported to correlate directly with the rate of proteolysis in severely traumatized patients?
- In the human trauma study, reduced actin and tubulin protein content was interpreted as being consistent with which finding?
- Which finding was reported as a marker of apoptosis in the skeletal muscle analysis of severely traumatized patients?
- A patient study finds that higher EEF1A1 expression is associated with a higher rate of muscle proteolysis. Which conclusion is justified by the supplied evidence?
- In the supplied VML tissue-engineering study, volumetric muscle loss is clinically important because the defect may:
- Which limitation of conventional reconstruction for large muscle defects was specifically noted in the supplied tissue-engineering study?
- In the 2008 PCL/collagen scaffold study, which fiber arrangement most strongly promoted muscle-cell alignment and myotube formation?
- Which conclusion is best supported by the PCL/collagen nanofiber study?
- In the 2021 electroactive-scaffold study, which cells were used to investigate proliferation and morphology on PCL and PCL-Ag NW fibers?
- Compared with neat PCL fibers, what proliferation result was reported for C2C12 cells on PCL-Ag NW nanocomposite fibers?
- Which electrical-stimulation conditions were included when C2C12 cells were studied on PCL-Ag NW scaffolds?
- The reported enhancement of C2C12 proliferation on PCL-Ag NW fibers was observed under which comparison described in the study abstract?
- Which fabrication approach was used to produce the PCL-Ag NW nanocomposite fiber bundles in the 2021 study?
- What is the most appropriate clinical interpretation of the reported PCL-Ag NW cell-proliferation findings?