Bone and soft tissue
Pathology · Topic 32
Source: NMC CBME Curriculum 2024 · Volume I · Pathology · Topic 32 · combined PDF page 202
Practice questions
- What tissue property does diffusion-weighted MRI indirectly reflect when assessing bone and soft-tissue tumors?
- A systematic review evaluates DWI for differentiating benign from malignant bone tumors. Which sensitivity range did it report across included studies?
- For benign–malignant differentiation of soft-tissue tumors, which specificity range was reported in the DWI systematic review?
- When DWI was assessed for correlation of chemotherapy response with histopathology in primary bone tumors, what sensitivity range was reported?
- A DWI result appears to favor malignancy in an indeterminate soft-tissue mass. Which interpretation best fits the evidence summarized in the systematic review?
- Which set of findings is identified as requiring integration for accurate sarcoma subtype diagnosis?
- In the systematic review of expert second opinions for bone and soft-tissue sarcoma histopathology, what did five studies report?
- A pathology service receives a biopsy suspicious for sarcoma with discordance between morphology and imaging. Which action is most consistent with the systematic review's recommendation?
- What practical contributions can gross examination provide when evaluating a bone or soft-tissue tumor resection specimen?
- A resection specimen has striking gross features suggestive of a particular sarcoma. Which statement best describes how those features should be used?
- In which sarcoma setting does the supplied liquid-biopsy review identify the best-supported evidence for ctDNA use in postoperative relapse prediction?
- For a translocation-associated sarcoma with a known fusion breakpoint, which liquid-biopsy approach is described as enabling highly specific longitudinal monitoring?
- Which liquid-biopsy strategy does the review identify as potentially relevant for sarcomas with complex karyotypes?
- A patient with low-volume sarcoma has an undetectable ctDNA result despite suspicious imaging. Which explanation is supported by the liquid-biopsy review?
- What is the current role of liquid biopsy relative to imaging-based surveillance in bone and soft-tissue sarcomas, according to the review?
- Which limitation of circulating tumor-cell analysis is specifically noted in the sarcoma liquid-biopsy review?
- In a meta-analysis of anlotinib for advanced bone and soft-tissue sarcomas, what pooled objective response rate was reported?
- What pooled disease control rate did the anlotinib meta-analysis report for advanced bone and soft-tissue sarcomas?
- What pooled median progression-free survival was reported in the meta-analysis of anlotinib for advanced bone and soft-tissue sarcomas?
- Which adverse event was most frequent among the three common all-grade treatment-related adverse events reported with anlotinib in the meta-analysis?
- Which adverse event had a reported grade 3–4 incidence of 7.9% with anlotinib in the supplied meta-analysis?
- A clinician interprets the favorable pooled disease control rate from the anlotinib meta-analysis as definitive proof of comparative superiority across all sarcoma subtypes. Which appraisal is most appropriate?
- A 28-year-old man has multiple lesions involving skin, bone, and soft tissue. Which molecular finding is associated with pseudomyogenic hemangioendothelioma in the supplied review and case report?
- Which clinical pattern is most consistent with the supplied description of pseudomyogenic hemangioendothelioma?
- In the long-term case report of pseudomyogenic hemangioendothelioma, what outcome was described after locoregional intraarterial epirubicin?