Macrocytic anemia
Pathology · Topic 15
Source: NMC CBME Curriculum 2024 · Volume I · Pathology · Topic 15 · combined PDF page 191
Practice questions
- Which mechanism defines megaloblastic anemia in the classification of macrocytic anemias?
- Which peripheral blood finding is described as one of the most sensitive and specific signs of megaloblastic anemia?
- Which red-cell morphology best favors megaloblastic anemia over liver-related macrocytosis?
- A blood film shows mild, uniform macrocytosis with round red cells. Which cause is most consistent with this pattern?
- In a patient with macrocytosis, which finding most strongly supports a megaloblastic process rather than reticulocytosis?
- Which is identified as the most common form of nonmegaloblastic macrocytosis in the cited review?
- Which set contains causes of adult macrocytic anemia listed in a practical review?
- A patient has macrocytosis and a raised reticulocyte count. Which paired causes should be considered?
- Which initial approach is recommended for most adults with macrocytosis in the practical review?
- Which laboratory group is specifically included in the investigation of macrocytic anemia?
- When investigating macrocytosis for possible vitamin deficiency, which combination of measurements is supported by the cited review?
- In the older diagnostic approach described in the literature, what was the purpose of the Schilling test in a patient with established B12 deficiency?
- Which statement about reticulocyte count is most consistent with the evaluation of macrocytosis?
- Which reticulocyte pattern is compatible with alcoholism, liver disease, or hypothyroidism as causes of macrocytosis?
- Which medication-related mechanism is included among causes of macrocytic anemia in the cited literature?
- A patient with macrocytosis has an otherwise unexplained, persistently abnormal blood count and concern for myelodysplasia. Which investigation may be required to confirm a suspected diagnosis?
- In infants and children, macrocytic or megaloblastic anemia is described as more often resulting from which broad process?
- Which nutritional deficiencies are most commonly linked to macrocytic or megaloblastic anemia in children in the cited review?
- A patient with Crohn disease develops macrocytic anemia. Which proposed explanation is reported in the supplied literature?
- Which description best characterizes pernicious anemia in the supplied clinical practice review?
- In a patient whose gastric histology is compatible with autoimmune gastritis, which additional tests may assist with diagnosis?
- A patient with newly diagnosed pernicious anemia has not had a recent endoscopy. What evaluation is advised in the supplied practice review?
- How should atrophic gastritis be confirmed according to the supplied clinical practice review?
- Which deficiencies should be evaluated in patients with atrophic gastritis, particularly when it is corpus-predominant?
- In a randomized trial of children with nutritional macrocytic-megaloblastic anemia, which route was associated with a greater median rise in hemoglobin at three months?
- In the same pediatric trial, which treatment group had the greater median increase in serum vitamin B12 at three months?