Systemic Pediatrics-Central Nervous system
Pediatrics · Topic 27
Source: NMC CBME Curriculum 2024 · Volume II · Pediatrics · Topic 27 · combined PDF page 346
Practice questions
- In the 2022 retrospective study of 51 patients with juvenile systemic lupus erythematosus, what proportion was diagnosed with juvenile neuropsychiatric SLE?
- In the j-NPSLE study, when was neuropsychiatric involvement diagnosed for most affected patients?
- Which CSF finding was significantly higher in active j-NPSLE with CNS involvement than in j-SLE without CNS involvement in the reported study?
- In paired samples from patients with j-NPSLE, what happened to CSF neopterin and IFN-α after neuropsychiatric features resolved during immunosuppressive treatment?
- The reported Spearman correlation between CSF neopterin and IFN-α in j-NPSLE was Rs = 0.832. Which interpretation is most appropriate?
- A child with j-SLE develops new neuropsychiatric symptoms. Which conclusion best reflects the evidence on routine tests and CSF biomarkers in the supplied study?
- At an oncology referral center, 38 of 891 patients referred as having primary brain tumors were ultimately found to have pseudotumoral CNS lesions. What proportion did this represent?
- Which etiologic group was most frequent among the pseudotumoral CNS lesions in the oncology-center series?
- Which symptom was most frequently recorded among the patients with pseudotumoral CNS lesions in the oncology-center study?
- Which statement about lesion imaging in the pseudotumoral CNS series is supported by the reported results?
- Which inference about biopsy is justified by the pseudotumoral CNS lesion study?
- What outcome was reported for patients with pseudotumoral CNS lesions in the oncology-center series?
- A child with a mass-like CNS lesion has imaging initially interpreted as a primary brain tumor. Which conclusion is most consistent with the pseudotumoral lesion study?
- In the 31-patient retinoblastoma CNS-metastasis series, which MRI manifestation was reported in the largest number of patients?
- In the retinoblastoma CNS-metastasis study, how many of the 27 patients tested had retinoblastoma cells detected in CSF?
- Which statement best interprets the CSF cytology findings in the retinoblastoma metastasis series?
- In 11 retinoblastoma patients with CNS metastases who received six cycles of systemic chemotherapy and had laboratory testing, what happened to serum NSE after treatment?
- What is the most appropriate conclusion from the reported fall in serum NSE after chemotherapy in 11 patients with CNS-metastatic retinoblastoma?
- Which outcome best describes the 31-patient CNS-metastatic retinoblastoma cohort at the end of follow-up?
- A child with retinoblastoma has suspected CNS spread. Which statement about the supplied CNS-metastasis study is accurate?
- Which statement about pediatric systemic and CNS vasculitis is supported by the supplied review?
- A child has systemic symptoms and a CNS abnormality that could reflect vasculitis, infection, or a genetic disorder. Based on the supplied pediatric vasculitis review, what is the best reasoning approach?