Chemotherapy
Pharmacology · Topic 8
Source: NMC CBME Curriculum 2024 · Volume I · Pharmacology · Topic 8 · combined PDF page 181
Practice questions
- In the supplied network meta-analysis of platinum-resistant or refractory ovarian cancer, which chemotherapy combinations were reported to improve overall and progression-free survival versus chemotherapy alone?
- For platinum-resistant or refractory ovarian cancer, which regimen did the network meta-analysis identify as offering an optimal balance of efficacy and safety among the assessed combinations?
- A patient with platinum-resistant ovarian cancer is being considered for a chemotherapy combination, and the team is particularly concerned about severe adverse events. Which combination was specifically associated with increased grade 3–4 adverse events in the reviewed analysis?
- According to the PROC network meta-analysis, which regimen was proposed as an alternative for a patient ineligible for anti-angiogenic therapy?
- An adult receiving chemotherapy has painful peripheral neuropathy. Which antidepressant had the strongest supportive evidence for reducing CIPN-related pain in the supplied systematic review?
- Which conclusion about preventing chemotherapy-induced peripheral neuropathy is best supported by the supplied systematic review?
- A patient with painful CIPN has only partial improvement on duloxetine. What conclusion about adding another analgesic is most consistent with the supplied review?
- Which statement best summarizes the evidence on chronomodulated chemotherapy in the supplied systematic review?
- A clinician proposes that giving chemotherapy at a particular time of day improves survival for all patients. Which qualification best reflects the supplied review?
- Most studies associating earlier immune-checkpoint-inhibitor administration with better outcomes were retrospective. How should this finding be interpreted?
- A retrospective analysis finds poorer systemic-therapy outcomes during winter and at higher latitudes. Which interpretation is most appropriate based on the supplied review?
- Higher vitamin D levels during immunotherapy were associated with better survival in the reviewed literature. What limitation should temper interpretation of this association?
- Across the symptom-network studies of adults with solid tumors receiving chemotherapy, which symptom was most frequently identified as a core symptom?
- A service plans to use fatigue as the sole symptom-management priority for every patient receiving chemotherapy. Which finding from the symptom-network review most strongly argues against a uniform approach?
- Which group contains the bridge symptoms reported most often in the chemotherapy symptom-network review?
- A longitudinal symptom-network analysis reports that sadness predicts later changes in appetite, distress, nausea, and other outcomes. How should this result be understood?
- In pediatric B-ALL, what was the overall direction of the disease-free-survival and overall-survival findings when blinatumomab was added to chemotherapy in the supplied meta-analysis?
- In the pediatric B-ALL meta-analysis, which outcome did not show a statistically significant improvement with blinatumomab-containing treatment?
- Which evidence limitation did the pediatric B-ALL meta-analysis identify when interpreting the effect of blinatumomab added to chemotherapy?
- The B-ALL meta-analysis found no statistically significant difference in pooled adverse-event rates between treatment groups. What additional qualification did the review provide?
- A pediatric oncology team is designing dietary support for a child with ALL receiving chemotherapy. Which approach is most consistent with the best-evidence review?
- Which set of topics was included in the dietary-management framework for children with ALL receiving chemotherapy?
- A meta-analysis of randomized trials evaluates Five-Element Music Therapy during chemotherapy. Which conclusion best reflects both its reported findings and the certainty of evidence?
- Why should the apparent benefits of Five-Element Music Therapy during chemotherapy be interpreted cautiously?
- A review describes chemotherapy and checkpoint inhibitors as possible host-preconditioning tools for future in vivo CAR-T approaches. Which interpretation is most appropriate?
- Which statement best describes the review's account of chemotherapy's effects on the T-cell compartment in cancer patients?
- Why does the in vivo CAR-T review emphasize the quality of T-cell memory phenotypes when considering chemotherapy-based host preconditioning?
- A systematic review of contemporary CIPN studies finds pain reductions with duloxetine and promising but limited results with topical amitriptyline. Which evidence-based summary is most appropriate?
- The PROC network meta-analysis included 22 randomized trials and 3,408 participants. Which statement best characterizes how its findings should be applied?
- A patient receiving chemotherapy reports fatigue, disturbed sleep, and poor appetite. What is the most defensible implication of the symptom-network review for assessment?
- A review of systemic cancer therapy reports associations between objective circadian disruption and poorer prognosis. What conclusion is justified from the supplied evidence?
- Which description most accurately matches the population and evidence base for the blinatumomab meta-analysis?