Respiratory system
Pharmacology · Topic 5
Source: NMC CBME Curriculum 2024 · Volume I · Pharmacology · Topic 5 · combined PDF page 179
Practice questions
- A team is using computational fluid dynamics to investigate how an inhaled medicine travels through the human respiratory tract. Which set of factors is identified as influencing aerosol transport in the reviewed literature?
- A researcher wants to predict how particles from an inhaled formulation move through a complex airway model. Which approach is specifically described as useful for this purpose?
- Two inhaled-aerosol simulations use the same particle formulation but different airway geometries and breathing patterns. Why might their predicted deposition differ?
- Which statement best reflects the reviewed evidence about respiratory ENaC inhibition in cystic fibrosis?
- A student is asked to identify a respiratory function associated with ENaC in the reviewed literature. Which is the best answer?
- Which finding about alveolar ENaC and acute lung injury/ARDS is reported in the supplied review?
- A review of respiratory ENaC research describes a shift beyond the channel's traditional fluid-transport role. Which broader area is highlighted?
- A question asks why glucocorticoid receptor alpha (GRα) is relevant during lung development. Which function is supported by the reviewed evidence?
- In the mature lung, which combination of functions is attributed to GRα in the supplied review?
- A review discussing glucocorticoid-related respiratory applications specifically links antenatal corticosteroids with which broad purpose?
- Which interpretation best captures how the supplied review characterizes GRα in the respiratory system?
- A respiratory disease research group is evaluating a proposed mechanism of cell death. Which description identifies ferroptosis as defined in the supplied review?
- An investigator is organizing the major mechanistic domains involved in ferroptosis. Which set best matches those highlighted in the supplied review?
- A clinician-scientist asks whether ferroptosis has been investigated in asthma and COPD. Which answer is most consistent with the supplied review?
- A research abstract proposes ferroptosis-related targets for future respiratory therapies. Which conclusion is justified by the supplied review?
- A new whole-lung aerosol model incorporates anatomical variation, breathing patterns, airflow, and particle characteristics. Which claim about its use is most consistent with the supplied review?