Bipolar disorders
Psychiatry · Topic 6
Source: NMC CBME Curriculum 2024 · Volume II · Psychiatry · Topic 6 · combined PDF page 353
Practice questions
- According to the CANMAT/ISBD 2018 guideline, which option is a first-line treatment for acute mania in bipolar I disorder?
- A patient with bipolar I disorder is being treated for acute mania. Which option below is included among first-line treatments in the CANMAT/ISBD 2018 guideline?
- Which option is included in the CANMAT/ISBD first-line list for acute mania, either alone or in combination?
- Which statement best represents the CANMAT/ISBD 2018 acute mania recommendations?
- A patient with bipolar I disorder is experiencing a depressive episode. Which option is listed as a first-line treatment in the CANMAT/ISBD 2018 guideline?
- Which combination is explicitly included as a first-line option for bipolar I depression in the CANMAT/ISBD 2018 guideline?
- Which medication is listed as a first-line option for bipolar I depression and also appears among first-line maintenance options?
- Which of the following is listed as a first-line option for bipolar I depression, either as monotherapy or as part of an adjunctive strategy?
- A clinician is initiating or switching maintenance treatment for bipolar I disorder. Which medication is included among first-line maintenance options in the CANMAT/ISBD 2018 guideline?
- Which statement best describes the guideline approach to continuing treatment from an acute episode into bipolar I maintenance?
- Which medication is included in the CANMAT/ISBD first-line lists for acute mania and bipolar I maintenance?
- Under the CANMAT/ISBD update for DSM-5 manic episodes with mixed features, which statement about treatment recommendations is accurate?
- For DSM-5 mania with mixed features, which medication is listed as a second-line option in the CANMAT/ISBD update?
- For DSM-5 depression with mixed features, which pair comprises second-line options in the CANMAT/ISBD update?
- A question asks for a first-line option for a DSM-IV-defined mixed episode, rather than a DSM-5 episode with mixed features. Which agent is listed as first-line for the DSM-IV-defined episode?
- Which medication is a second-line option for DSM-IV-defined mixed episodes according to the CANMAT/ISBD mixed-presentation update?
- Following a DSM-IV-defined mixed episode, which medication is identified as a first-line maintenance treatment in the CANMAT/ISBD update?
- An ISBD task force is designing a treatment trial for cognitive impairment in bipolar disorder. Which participant-selection strategy is recommended?
- For a bipolar disorder cognition treatment trial, which outcome strategy is recommended by the ISBD task force?
- Which participant group does the ISBD task force recommend including in bipolar cognition trials?
- In an ISBD-recommended bipolar cognition trial, what approach is advised for non-study medications?
- A 2025 meta-analysis reports a prevalence estimate for poor sleep quality in bipolar disorder during euthymia. Which estimate is closest to the reported value?
- According to a 2025 meta-analysis, which sleep problem was reported in approximately 63% of patients with bipolar disorder during the depressive phase?
- Which sleep pattern was associated with manic or mixed phases of bipolar disorder in the 2025 meta-analysis?
- A meta-analysis comparing euthymic bipolar disorder with controls found worse sleep quality and which additional sleep characteristics in the bipolar group?
- A 2025 systematic review pooled the prevalence of mixed features across bipolar episodes. Which estimate best represents mixed features in bipolar depression?
- In a 2025 systematic review, how did pooled mixed-feature prevalence in bipolar depression compare with prevalence in bipolar manic or hypomanic episodes?
- A systematic review found that prevalence estimates of mixed features differed according to definition. What was the general effect of using a broader criterion of at least three opposite-polarity features rather than DSM-5 criteria?
- An umbrella review comparing environmental risk factors across psychiatric disorders identified which factor as a robust transdiagnostic risk factor for schizophrenia, bipolar disorder, and depressive disorders?
- When interpreting umbrella-review findings on environmental risk factors for bipolar disorder, which methodological caution was emphasized by the authors?